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LARGE antibody (AA 365-398)

LARGE Reactivity: Human WB Host: Rabbit Polyclonal RB55257 unconjugated
Catalog No. ABIN6243442
  • Target See all LARGE Antibodies
    LARGE (Like-Glycosyltransferase (LARGE))
    Binding Specificity
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 365-398
    Reactivity
    • 9
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Human
    Host
    • 5
    • 2
    • 2
    Rabbit
    Clonality
    • 7
    • 2
    Polyclonal
    Conjugate
    • 8
    • 1
    This LARGE antibody is un-conjugated
    Application
    • 7
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Predicted Reactivity
    C, Zf, M
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This LARGE antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 365-398 amino acids from the Central region of human LARGE.
    Clone
    RB55257
    Isotype
    Ig Fraction
    Top Product
    Discover our top product LARGE Primary Antibody
  • Application Notes
    WB: 1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Expiry Date
    6 months
  • Target
    LARGE (Like-Glycosyltransferase (LARGE))
    Alternative Name
    LARGE (LARGE Products)
    Synonyms
    gyltl1b antibody, gyltl1b-b antibody, mdc1d antibody, MDC1D antibody, MDDGA6 antibody, MDDGB6 antibody, BPFD36 antibody, Gyltl1a antibody, Mbp-1 antibody, Mbp1 antibody, enr antibody, fg antibody, froggy antibody, mKIAA0609 antibody, myd antibody, NV15834 antibody, DKFZp459G0120 antibody, LARGE xylosyl- and glucuronyltransferase 1 L homeolog antibody, LARGE xylosyl- and glucuronyltransferase 1 antibody, glycosyltransferase-like protein LARGE1 antibody, like-glycosyltransferase antibody, large1.L antibody, LARGE1 antibody, Large1 antibody, large1 antibody, LOC100118066 antibody, LARGE antibody, Large antibody
    Background
    Bifunctional glycosyltransferase with both xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine- beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1) (PubMed:< a href="http://www.uniprot.org/citations/22223806" target="_blank">22223806). Phosphorylated O- mannosyl trisaccharid is required for binding laminin G-like domain-containing extracellular proteins with high affinity and plays a key role in skeletal muscle function and regeneration. LARGE elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure initiated by B3GNT1/B4GAT1 by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide (PubMed:< a href="http://www.uniprot.org/citations/25279699" target="_blank">25279699).
    Molecular Weight
    88066
    UniProt
    O95461
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