ALK antibody (AA 636-666)

Catalog No. ABIN6243477

The Rabbit Polyclonal anti-ALK antibody has been validated for IHC (p) and WB. It is suitable to detect ALK in samples from Human.

Quick Overview for ALK antibody (AA 636-666) (ABIN6243477)

Target: ALK (Anaplastic Lymphoma Receptor tyrosine Kinase (ALK))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ALK antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)

Clone: RB15425

Product Details anti-ALK Antibody

Binding Specificity: AA 636-666

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This ALK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 636-666 amino acids from the Central region of human ALK.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for ALK

Target: ALK (Anaplastic Lymphoma Receptor tyrosine Kinase (ALK))

Alternative Name: ALK

Background: ALK, a member of the insulin receptor subfamily of Tyr protein kinases, is an orphan receptor. It appears to play an important role in the normal development and function of the nervous system. This Type I membrane protein is expressed in brain and CNS and in the small intestine and testis, but not in normal lymphoid cells. A form of non-Hodgkin's lymphoma is characterized by a chromosomal translocation t(2,5)(p23,q35) that involves NPM1 and ALK. The protein contains 1 LDL-receptor class A domain and 2 putative MAM domains.

Molecular Weight: 176442

NCBI Accession: NP_004295

UniProt: Q9UM73

Pathways: RTK Signaling