Transferrin Receptor antibody (AA 649-677)

Catalog No. ABIN6243624

The Mouse Monoclonal anti-Transferrin Receptor antibody is suitable to detect Transferrin Receptor in samples from Human. It has been validated for WB.

Quick Overview for Transferrin Receptor antibody (AA 649-677) (ABIN6243624)

Target: Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Transferrin Receptor antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 514CT23-4-1

Product Details anti-Transferrin Receptor Antibody

Binding Specificity: AA 649-677

Purification: This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.

Immunogen: This TFRC antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 649-677 amino acids from human TFRC.

Isotype: IgM

Application Details

Application Notes: WB: 1:1000. WB: 1:100~250

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for Transferrin Receptor

Target: Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))

Alternative Name: TFRC

Background: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.

Molecular Weight: 84871

NCBI Accession: NP_001121620, NP_003225

UniProt: P02786

Pathways: Transition Metal Ion Homeostasis