CHMP4A antibody (C-Term)

Catalog No. ABIN6243822

The Rabbit Polyclonal anti-CHMP4A antibody is suitable to detect CHMP4A in samples from Human. It has been validated for WB.

Quick Overview for CHMP4A antibody (C-Term) (ABIN6243822)

Target: CHMP4A (Charged Multivesicular Body Protein 4A (CHMP4A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHMP4A antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB51700

Product Details anti-CHMP4A Antibody

Binding Specificity: AA 205-239, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CHMP4A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 205-239 amino acids from the C-terminal region of human CHMP4A.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for CHMP4A

Target: CHMP4A (Charged Multivesicular Body Protein 4A (CHMP4A))

Alternative Name: CHMP4A

Background: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4A filaments can promote or stabilize negative curvature and outward budding. Via its interaction with PDCD6IP involved in HIV-1 p6- and p9-dependent virus release.

Molecular Weight: 25098

UniProt: Q9BY43