EPH Receptor B4 antibody (C-Term)

Catalog No. ABIN6243858

The Rabbit Polyclonal anti-EPH Receptor B4 antibody is suitable to detect EPH Receptor B4 in samples from Human and Mouse. It has been validated for WB.

Quick Overview for EPH Receptor B4 antibody (C-Term) (ABIN6243858)

Target: EPH Receptor B4 (EPHB4)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EPH Receptor B4 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB50408

Product Details anti-EPH Receptor B4 Antibody

Binding Specificity: AA 889-923, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Mouse Ephb4 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 889-923 amino acids from the C-terminal region of Mouse Ephb4.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for EPH Receptor B4

Target: EPH Receptor B4 (EPHB4)

Alternative Name: Ephb4

Background: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4- mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis.

Molecular Weight: 108848

UniProt: P54761

Pathways: RTK Signaling