IP3 Receptor antibody (pSer1756)

Catalog No. ABIN6255024

The Rabbit Polyclonal anti-IP3 Receptor antibody is suitable to detect IP3 Receptor in samples from Human, Rat and Mouse. It has been validated for WB, IF and ICC.

Quick Overview for IP3 Receptor antibody (pSer1756) (ABIN6255024)

Target: IP3 Receptor (ITP-R83A) (Inositol 1,4,5,-Tris-Phosphate Receptor (ITP-R83A))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IP3 Receptor antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Product Details anti-IP3 Receptor Antibody

Binding Specificity: pSer1756

Purpose: Phospho-IP3 Receptor (Ser1756) Antibody

Specificity: Phospho-IP3 Receptor (Ser1756) Antibody detects endogenous levels of IP3 Receptor only when phosphorylated at Ser1756.

Purification: The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.

Immunogen: A synthesized peptide derived from RAT IP3 Receptor(P29994) around the phosphorylation site of Ser1756. This site is equivalent to Ser1764 in the human IP3 receptor sequence.

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000, IF/ICC 1:100-1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for IP3 Receptor

Target: IP3 Receptor (ITP-R83A) (Inositol 1,4,5,-Tris-Phosphate Receptor (ITP-R83A))

Alternative Name: IP3 Receptor

Background:

Description: Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate (PubMed:27108797). Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity).

Gene: ITPR1

Molecular Weight: 314kDa

Gene ID: 3708

UniProt: Q14643

Pathways: Fc-epsilon Receptor Signaling Pathway, Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma