RYR2 antibody (pSer2814)

Catalog No. ABIN6256236

The Rabbit Polyclonal anti-RYR2 antibody is suitable to detect RYR2 in samples from Human and Dog. It has been validated for IHC and WB.

Quick Overview for RYR2 antibody (pSer2814) (ABIN6256236)

Target: RYR2 (Ryanodine Receptor 2 (Cardiac) (RYR2))

Reactivity: Human, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RYR2 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Product Details anti-RYR2 Antibody

Binding Specificity: pSer2814

Purpose: Phospho-RYR2 (Ser2814) Antibody

Specificity: Phospho-RYR2( Ser2814) Antibody detects endogenous levels of RYR2.

Predicted Reactivity: Bovine,Horse,Sheep,Rabbit

Purification: The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.

Immunogen: A synthesized peptide derived from human RYR2 around the phosphorylation site of Ser2814.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for RYR2

Target: RYR2 (Ryanodine Receptor 2 (Cardiac) (RYR2))

Alternative Name: RYR2

Background:

Description: Calcium channel that mediates the release of Ca2+ from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca2+ levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.

Gene: RYR2

Molecular Weight: 564 kDa

Gene ID: 6262

UniProt: Q92736

Pathways: Myometrial Relaxation and Contraction