RIN1 antibody (C-Term)

Catalog No. ABIN6257477

This Rabbit Polyclonal antibody specifically detects RIN1 in WB, ELISA, IF and ICC. It exhibits reactivity toward Human, Rat and Mouse.

Quick Overview for RIN1 antibody (C-Term) (ABIN6257477)

Target: RIN1 (Ras and Rab Interactor 1 (RIN1))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RIN1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Product Details anti-RIN1 Antibody

Binding Specificity: C-Term

Specificity: RIN1 Antibody detects endogenous levels of total RIN1.

Predicted Reactivity: Pig,Horse,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human RIN1, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for RIN1

Target: RIN1 (Ras and Rab Interactor 1 (RIN1))

Alternative Name: RIN1

Background:

Description: Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis.

Gene: RIN1

Molecular Weight: 84 kDa

Gene ID: 9610

UniProt: Q13671