Chp2 antibody (Internal Region)

Catalog No. ABIN6258442

The Rabbit Polyclonal anti-Chp2 antibody (ABIN6258442) specifically detects Chp2 in WB, IF, ICC and IHC. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Chp2 antibody (Internal Region) (ABIN6258442)

Target: Chp2

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Chp2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (IHC)

Product Details anti-Chp2 Antibody

Binding Specificity: Internal Region

Purpose: CHP2 Antibody

Specificity: CHP2 Antibody detects endogenous levels of total CHP2.

Predicted Reactivity: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human CHP2, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for Chp2

Target: Chp2

Background:

Description: Functions as an integral cofactor in cell  pH regulation by controlling plasma membrane-type Na+/H+ exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing  pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus.

Gene: CHP2

Molecular Weight: 22 kDa

Gene ID: 63928

UniProt: O43745