CLN5 antibody (Internal Region)

Catalog No. ABIN6259553

Product Details anti-CLN5 Antibody

Target: CLN5 (Ceroid-Lipofuscinosis, Neuronal 5 (CLN5))

Binding Specificity: Internal Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CLN5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity: CLN5 Antibody detects endogenous levels of total CLN5.

Predicted Reactivity: Pig,Bovine,Sheep,Rabbit,Dog,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human CLN5, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for CLN5

Target: CLN5 (Ceroid-Lipofuscinosis, Neuronal 5 (CLN5))

Alternative Name: CLN5 (CLN5 Products)

Synonyms: NCL antibody, A730075N08Rik antibody, CLN5, intracellular trafficking protein antibody, ceroid-lipofuscinosis, neuronal 5 antibody, CLN5 antibody, Cln5 antibody

Background:

Description: Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane (PubMed:22431521).

Gene: CLN5

Molecular Weight: 46 kDa

Gene ID: 1203

UniProt: O75503