Aurora Kinase C antibody (N-Term)

Catalog No. ABIN6260157

The Rabbit Polyclonal anti-Aurora Kinase C antibody has been validated for WB and ELISA. It is suitable to detect Aurora Kinase C in samples from Human.

Quick Overview for Aurora Kinase C antibody (N-Term) (ABIN6260157)

Target: Aurora Kinase C (AURKC)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Aurora Kinase C antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Aurora Kinase C Antibody

Binding Specificity: N-Term

Specificity: AurB/C Antibody detects endogenous levels of total AurB/C.

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human AurB/C, corresponding to a region within N-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for Aurora Kinase C

Target: Aurora Kinase C (AURKC)

Alternative Name: AURKC

Background:

Description: Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.

Gene: AURKC

Molecular Weight: 36 kDa

Gene ID: 6795

UniProt: Q9UQB9

Pathways: Cell Division Cycle, Maintenance of Protein Location