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CD4 antibody (C-Term)

The Rabbit Polyclonal anti-CD4 antibody has been validated for WB and ELISA. It is suitable to detect CD4 in samples from Human and Mouse.
Catalog No. ABIN6260622

Quick Overview for CD4 antibody (C-Term) (ABIN6260622)

Target

See all CD4 Antibodies
CD4

Reactivity

  • 422
  • 230
  • 121
  • 48
  • 30
  • 24
  • 22
  • 18
  • 17
  • 12
  • 11
  • 11
  • 11
  • 10
  • 10
  • 10
  • 9
  • 9
  • 9
  • 5
  • 4
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Human, Mouse

Host

  • 427
  • 165
  • 126
  • 7
  • 3
  • 3
  • 1
  • 1
Rabbit

Clonality

  • 572
  • 153
  • 5
Polyclonal

Conjugate

  • 244
  • 71
  • 61
  • 50
  • 38
  • 12
  • 11
  • 9
  • 9
  • 9
  • 9
  • 9
  • 8
  • 8
  • 8
  • 8
  • 8
  • 7
  • 7
  • 7
  • 7
  • 7
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 4
  • 4
  • 4
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
This CD4 antibody is un-conjugated

Application

  • 563
  • 219
  • 158
  • 120
  • 96
  • 79
  • 68
  • 57
  • 56
  • 41
  • 39
  • 31
  • 10
  • 8
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  • 6
  • 5
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), ELISA
  • Binding Specificity

    • 32
    • 31
    • 26
    • 16
    • 16
    • 16
    • 16
    • 15
    • 10
    • 9
    • 8
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term

    Specificity

    CD4 Antibody detects endogenous levels of total CD4.

    Predicted Reactivity

    Pig,Horse,Rabbit,Dog

    Purification

    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).

    Immunogen

    A synthesized peptide derived from human CD4, corresponding to a region within C-terminal amino acids.

    Isotype

    IgG
  • Application Notes

    WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 mg/mL

    Buffer

    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    -20 °C

    Storage Comment

    Store at -20 °C. Stable for 12 months from date of receipt.

    Expiry Date

    12 months
  • Target

    CD4

    Alternative Name

    CD4

    Background

    Description: Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.

    Gene: CD4

    Molecular Weight

    55kDa

    Gene ID

    920

    UniProt

    P01730

    Pathways

    TCR Signaling, Maintenance of Protein Location, CXCR4-mediated Signaling Events
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