KCNE1 antibody (Internal Region)

Catalog No. ABIN6262741

The Rabbit Polyclonal anti-KCNE1 antibody (ABIN6262741) specifically detects KCNE1 in WB, ELISA, IHC, IF and ICC. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for KCNE1 antibody (Internal Region) (ABIN6262741)

Target: KCNE1 (Potassium Voltage-Gated Channel, Isk-Related Family, Member 1 (KCNE1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KCNE1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Product Details anti-KCNE1 Antibody

Binding Specificity: Internal Region

Specificity: KCNE1 Antibody detects endogenous levels of total KCNE1.

Predicted Reactivity: Pig,Bovine,Horse,Sheep

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human KCNE1, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for KCNE1

Target: KCNE1 (Potassium Voltage-Gated Channel, Isk-Related Family, Member 1 (KCNE1))

Alternative Name: KCNE1

Background:

Description: Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (PubMed:19219384). Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr).

Gene: KCNE1

Molecular Weight: 15kDa

Gene ID: 3753

UniProt: P15382

Pathways: Sensory Perception of Sound