NCOR2 antibody (C-Term)

Catalog No. ABIN6263545

This anti-NCOR2 antibody is a Rabbit Polyclonal antibody detecting NCOR2 in WB and ELISA. Suitable for Human and Mouse.

Quick Overview for NCOR2 antibody (C-Term) (ABIN6263545)

Target: NCOR2 (Nuclear Receptor Co-Repressor 2 (NCOR2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NCOR2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-NCOR2 Antibody

Binding Specificity: C-Term

Specificity: NCOR2 Antibody detects endogenous levels of total NCOR2.

Predicted Reactivity: Pig,Zebrafish,Bovine,Horse,Sheep,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human NCOR2, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for NCOR2

Target: NCOR2 (Nuclear Receptor Co-Repressor 2 (NCOR2))

Alternative Name: NCOR2

Background:

Description: Transcriptional corepressor. Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival.

Gene: NCOR2

Molecular Weight: 274 kDa

Gene ID: 9612

UniProt: Q9Y618

Pathways: Notch Signaling, Carbohydrate Homeostasis, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha