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STAT1 antibody (Signal Transducer and Activator of Transcription 1, 91kDa) Primary Antibody

STAT1 Reactivity: Human, Mouse, Rat ELISA, ICC, IF, IHC, IP, WB Host: Rabbit Polyclonal unconjugated
Pubmed (2)
Catalog No. ABIN6265311
$390.77
Plus shipping costs $45.00
100 μL ABIN6265311
100 μL ABIN6265311
local_shipping Shipping to: United States
Delivery in 8 to 9 Business Days
  • Target
    STAT1
    Reactivity
    Human, Mouse, Rat
    • 269
    • 142
    • 139
    • 22
    • 20
    • 20
    • 17
    • 15
    • 12
    • 9
    • 8
    • 5
    • 4
    • 4
    • 2
    • 1
    • 1
    Host
    Rabbit
    Clonality
    Polyclonal
    Conjugate
    This STAT1 antibody is un-conjugated
    • 167
    • 14
    • 10
    • 9
    • 9
    • 9
    • 8
    • 8
    • 7
    • 7
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    Application
    ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blotting (WB)
    • 197
    • 87
    • 75
    • 55
    • 55
    • 42
    • 22
    • 11
    • 10
    • 8
    • 4
    • 4
    • 2
    • 1
    • 1
    Specificity
    STAT1 Antibody detects endogenous levels of total STAT1
    Cross-Reactivity
    Human, Mouse (Murine), Rat (Rattus)
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human STAT1
    Isotype
    IgG
  • Application Notes
    WB 1:500-1:2000 IHC 1:50-1:200 IP, IF/ICC 1:100-1:500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C.Stable for 12 months from date of receipt
    Expiry Date
    12 months
  • Liu, Wu, Zhu, Li, Liu: "IRG1 increases MHC class I level in macrophages through STAT-TAP1 axis depending on NADPH oxidase mediated reactive oxygen species." in: International immunopharmacology, Vol. 48, pp. 76-83, 2018 (PubMed).

    Chen, Zhou, Liu, Huang, Liu, Kang, Chen, Guo, Zhu, Sun: "Combination of gemcitabine and erlotinib inhibits recurrent pancreatic cancer growth in mice via the JAK-STAT pathway." in: Oncology reports, Vol. 39, Issue 3, pp. 1081-1089, 2018 (PubMed).

  • Target
    STAT1
    Alternative Name
    STAT1 (STAT1 Antibody Abstract)
    Synonyms
    CANDF7, ISGF-3, STAT91, 2010005J02Rik, AA408197, XStat1, STAT4, DD6G4-4, STAT, STAT1, dZ182H3.3, si:by134g18.2, si:by51f19.1, si:dz182h3.3, si:dz199m19.1, si:dz73o4.2, stat1, signal transducer and activator of transcription 1, signal transducer and activator of transcription 1 L homeolog, signal transducer and activator of transcription 1, 91kDa, signal transducer and activator of transcription 4, signal transducer and activator of transcription 1a, STAT1, Stat1, stat1.L, stat4, stat1a
    Background

    Description: Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus (PubMed:28753426). ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated (PubMed:26479788). It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.

    Gene: STAT1

    Molecular Weight
    84kDa
    Gene ID
    6772
    UniProt
    P42224
    Pathways
    JAK-STAT Signaling, RTK Signaling, Interferon-gamma Pathway, Response to Growth Hormone Stimulus, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Hepatitis C, CXCR4-mediated Signaling Events
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