Syntaxin 17 antibody (C-Term)

Catalog No. ABIN6265405

The Rabbit Polyclonal anti-Syntaxin 17 antibody (ABIN6265405) specifically detects Syntaxin 17 in WB and IHC. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Syntaxin 17 antibody (C-Term) (ABIN6265405)

Target: Syntaxin 17 (STX17)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Syntaxin 17 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-Syntaxin 17 Antibody

Binding Specificity: C-Term

Purpose: Syntaxin 17 Antibody

Specificity: Syntaxin 17 Antibody detects endogenous levels of total Syntaxin 17.

Predicted Reactivity: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human Syntaxin 17, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for Syntaxin 17

Target: Syntaxin 17 (STX17)

Alternative Name: Syntaxin 17

Background:

Description: SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane (PubMed:23217709, PubMed:25686604). May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi (PubMed:21545355).

Gene: STX17

Molecular Weight: 33 kDa

Gene ID: 55014

UniProt: P56962

Pathways: Synaptic Vesicle Exocytosis