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TICAM1 antibody (Internal Region)

TICAM1 Reactivity: Human, Mouse, Rat WB, IHC, ELISA, ICC, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6265566
  • Target See all TICAM1 Antibodies
    TICAM1 (Toll-Like Receptor Adaptor Molecule 1 (TICAM1))
    Binding Specificity
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivity
    • 24
    • 8
    • 2
    • 2
    Human, Mouse, Rat
    Host
    • 22
    • 3
    • 3
    Rabbit
    Clonality
    • 25
    • 3
    Polyclonal
    Conjugate
    • 21
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TICAM1 antibody is un-conjugated
    Application
    • 20
    • 6
    • 6
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)
    Specificity
    TICAM1 Antibody detects endogenous levels of total TICAM1.
    Predicted Reactivity
    Pig,Zebrafish,Bovine,Horse,Sheep,Dog,Chicken
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human TICAM1, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product TICAM1 Primary Antibody
  • Application Notes
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C. Stable for 12 months from date of receipt.
    Expiry Date
    12 months
  • Target
    TICAM1 (Toll-Like Receptor Adaptor Molecule 1 (TICAM1))
    Alternative Name
    TICAM1 (TICAM1 Products)
    Synonyms
    IIAE6 antibody, MyD88-3 antibody, PRVTIRB antibody, TICAM-1 antibody, TRIF antibody, AW046014 antibody, AW547018 antibody, trif antibody, toll like receptor adaptor molecule 1 antibody, toll-like receptor adaptor molecule 1 antibody, TICAM1 antibody, Ticam1 antibody, ticam1 antibody
    Background

    Description: Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively.

    Gene: TICAM1

    Molecular Weight
    76kDa
    Gene ID
    148022
    UniProt
    Q8IUC6
    Pathways
    TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades
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