TOX3 antibody (AA 200-400)

Catalog No. ABIN6294379

This Mouse Monoclonal antibody specifically detects TOX3 in IHC. It exhibits reactivity toward Human.

Quick Overview for TOX3 antibody (AA 200-400) (ABIN6294379)

Target: TOX3 (TOX High Mobility Group Box Family Member 3 (TOX3))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TOX3 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-TOX3 Antibody

Binding Specificity: AA 200-400

Purpose: Mouse anti-Human TOX-3 Antibody [IHC only]

Specificity: Cytoplasmic & nuclear

Purification: A recombinant fragment (139 amino acid residues around aa 200-400) from the human protein was used as the immunogen for the TOX-3 antibody.

Immunogen: A recombinant fragment (139 amino acid residues around aa 200-400) from the human protein was used as the immunogen for the TOX-3 antibody.

Application Details

Application Notes: Prediluted format : incubate for 30 min at RT (2)

Restrictions: For Research Use only

Handling

Buffer: Prediluted in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, For IHC use only

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Target Details for TOX3

Target: TOX3 (TOX High Mobility Group Box Family Member 3 (TOX3))

Alternative Name: TOX high mobility group box family member 3

Background:

Target Description: It recognizes an ~63 kDa protein, which is identified as TOX3. It contains a high mobility group (HMG)-box, which regulates Ca2+-dependent transcription in neurons through interaction with the cAMP-response-element-binding protein (CREB). TOX3 appears to be associated with breast cancer susceptibility and is expressed downstream of a cytoprotective cascade together with CITED1, a transcriptional regulator that does not bind directly to DNA. TOX3 is predominantly expressed in the brain and forms homodimers. TOX3 overexpression protects neuronal cells from cell death caused by endoplasmic reticulum stress or BAX overexpression through the induction of anti-apoptotic transcripts and repression of pro-apoptotic transcripts.

Gene Symbol: TOX3///CAGF9///TNRC9

Gene ID: 27324

UniProt: O15405

Pathways: Chromatin Binding