Ubiquitin Hydrolase Isozyme L1 (C-Term) antibody

Catalog No. ABIN6294652

This Mouse Monoclonal antibody specifically detects Ubiquitin Hydrolase Isozyme L1 in IHC. It exhibits reactivity toward Human, Rat, Cow, Mouse and Pig.

Quick Overview for Ubiquitin Hydrolase Isozyme L1 (C-Term) antibody (ABIN6294652)

Target: Ubiquitin Hydrolase Isozyme L1

Reactivity: Human, Rat, Cow, Mouse, Pig

Host: Mouse

Clonality: Monoclonal

Conjugate: Un-conjugated

Application: Immunohistochemistry (IHC)

Product Details

Binding Specificity: C-Term

Purpose: Mouse anti-Human/Mouse/Rat/Cow/Pig PGP9.5 Antibody UchL1 [IHC only]

Specificity: Cytoplasmic

Purification: Native protein from brain was used as the immunogen for this PGP9.5 antibody.

Immunogen: Native protein from brain was used as the immunogen for this PGP9.5 antibody.

Application Details

Application Notes: Prediluted format : incubate for 30 min at RT (2)

Restrictions: For Research Use only

Handling

Buffer: Prediluted in 1X PBS ( pH 7.4) with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, For IHC use only

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Target Details

Target: Ubiquitin Hydrolase Isozyme L1

Background:

Target Description: This antibody specifically reacts with a protein of 20-30 kDa, identified as PGP9.5, also known as ubiquitin carboxyl-terminal hydrolase-1 (UchL1). Initially, expression in normal tissues was reported in neurons and neuroendocrine cells but later it was found in distal renal tubular epithelium, spermatogonia, Leydig cells, oocytes, melanocytes, prostatic secretory epithelium, ejaculatory duct cells, epididymis, mammary epithelial cells, Merkel cells, and dermal fibroblasts. PGP9.5 antibody has been used to show the protein to be a useful prognostic indicator of colorectal, pancreatic and gall bladder cancer. A mutation in the gene is believed to cause a form of Parkinson's disease.

Gene Symbol: UCHL1

Gene ID: 7345

UniProt: P09936