XRCC6 antibody

Catalog No. ABIN6295976

The Mouse Monoclonal anti-XRCC6 antibody has been validated for FACS. It is suitable to detect XRCC6 in samples from Human.

Quick Overview for XRCC6 antibody (ABIN6295976)

Target: XRCC6 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 6 (XRCC6))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This XRCC6 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Product Details anti-XRCC6 Antibody

Purpose: Mouse anti-Human Ku70 + Ku80 Antibody [Sodium Azide Free]

Specificity: Nuclear

Purification: A human cell nuclear fraction was used as the immunogen for this Ku70 + Ku80 antibody.

Immunogen: A human cell nuclear fraction was used as the immunogen for this Ku70 + Ku80 antibody.

Application Details

Application Notes: Flow cytometry: 0.5-1 μg/10e6 cells

Restrictions: For Research Use only

Handling

Buffer: In 1X PBS ( pH 7.4), BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Target Details for XRCC6

Target: XRCC6 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 6 (XRCC6))

Alternative Name: X-ray repair cross-complementing protein 6

Background:

Target Description: Together, Ku70 and Ku80 make up the Ku heterodimer, which binds to DNA double-strand break ends and is required for the non-homologous end joining (NHEJ) pathway of DNA repair. It is also required for V(D)J recombination, which utilizes the NHEJ pathway to promote antigen diversity in the mammalian immune system. In addition to its role in NHEJ, Ku is also required for telomere length maintenance and subtelomeric gene silencing. Ku was originally identified when patients with systemic lupus erythematosus were found to have high levels of autoantibodies to the protein. [Wiki]

Gene Symbol: XRCC6///G22P1

Gene ID: 2547

UniProt: P12956

Pathways: DNA Damage Repair