JUP antibody

Catalog No. ABIN6296917

This Mouse Monoclonal antibody specifically detects JUP in WB, IF and IP. It exhibits reactivity toward Human, Mouse, Rat, Chicken, Cow, Dog and Cat.

Quick Overview for JUP antibody (ABIN6296917)

Target: JUP (Junction Plakoglobin (JUP))

Reactivity: Human, Mouse, Rat, Chicken, Cow, Dog, Cat

Host: Mouse

Clonality: Monoclonal

Conjugate: This JUP antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)

Product Details anti-JUP Antibody

Purpose: Mouse anti-Human/Mouse/Rat/Cat/Dog/Chicken/Cow Gamma Catenin Antibody / Plakoglobin [Sodium Azide Free]

Specificity: Cell surface, cytoplasmic, cell junctions

Purification: Recombinant full length chicken gamma Catenin was used as the immunogen for the Plakoglobin antibody.

Immunogen: Recombinant full length chicken gamma Catenin was used as the immunogen for the Plakoglobin antibody.

Application Details

Application Notes: Immunofluorescence: 1-2 μg/mL
WB: 0.5-1 μg/mL
Immunoprecipitation: suitable

Restrictions: For Research Use only

Handling

Buffer: In 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Target Details for JUP

Target: JUP (Junction Plakoglobin (JUP))

Alternative Name: Junction plakoglobin

Background:

Target Description: Plakoglobin, or gamma Catenin, is a common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of Plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity). [UniProt]

Gene Symbol: JUP///CTNNG///DP3

Gene ID: 3728

UniProt: P14923

Pathways: Cell-Cell Junction Organization, Maintenance of Protein Location