PAX6 antibody

Catalog No. ABIN6297257

The Mouse Monoclonal anti-PAX6 antibody has been validated for WB, IF and FACS. It is suitable to detect PAX6 in samples from Human, Mouse, Rat and Chicken.

Quick Overview for PAX6 antibody (ABIN6297257)

Target: PAX6 (Paired Box 6 (PAX6))

Reactivity: Human, Mouse, Rat, Chicken

Host: Mouse

Clonality: Monoclonal

Conjugate: This PAX6 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Product Details anti-PAX6 Antibody

Purpose: Mouse anti-Human/Mouse/Rat/Chicken PAX6 Antibody [Sodium Azide Free]

Specificity: Nuclear

Purification: Recombinant human PAX6 protein was used as the immunogen for this antibody.

Immunogen: Recombinant human PAX6 protein was used as the immunogen for this antibody.

Application Details

Application Notes: FACS: 0.5-1 μg/million cells
IF: 0.5-1 μg/mL
WB: 0.5-1 μg/mL,

Restrictions: For Research Use only

Handling

Buffer: In 1X PBS ( pH 7.4), BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Target Details for PAX6

Target: PAX6 (Paired Box 6 (PAX6))

Alternative Name: Paired box protein Pax-6

Background:

Target Description: PAX genes contain paired domains with strong homology to genes in Drosophila, which are involved in programming early development. Lesions in the PAX6 gene account for most cases of aniridia, a congenital malformation of the eye, chiefly characterized by iris hypoplasia, which can cause blindness. PAX6 is involved in other anterior segment malformations besides aniridia, such as Peters ' anomaly, a major error in the embryonic development of the eye with corneal clouding with variable iridolenticulocorneal adhesions. The PAX6 gene encodes a transcriptional regulator that recognizes target genes through its paired-type DNA-binding domain. The paired domain is composed of two distinct DNA-binding subdomains, the amino-terminal subdomain and the carboxy-terminal subdomain, which bind respective consensus DNA sequences. The human PAX6 gene produces two alternatively spliced isoforms that have the distinct structure of the paired domain.

Gene Symbol: PAX6///AN2

Gene ID: 5080

UniProt: P26367

Pathways: Peptide Hormone Metabolism, Carbohydrate Homeostasis