CD80 antibody

Catalog No. ABIN6297276

The Mouse Monoclonal anti-CD80 antibody (ABIN6297276) specifically detects CD80 in FACS, ELISA, IF and Coat. The antibody is reactive with Human samples.

Quick Overview for CD80 antibody (ABIN6297276)

Target: CD80

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD80 antibody is un-conjugated

Application: Flow Cytometry (FACS), ELISA, Immunofluorescence (IF), Coating (Coat)

Product Details anti-CD80 Antibody

Purpose: Mouse anti-Human CD80 Antibody / B7-1 [Sodium Azide Free]

Specificity: Cytoplasmic, membranous

Purification: Recombinant human protein used as the immunogen for the CD80 antibody.

Immunogen: Recombinant human protein used as the immunogen for the CD80 antibody.

Application Details

Application Notes: Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 1-2 μg/mL,ELISA (protein): order BSA free formulation for coating

Restrictions: For Research Use only

Handling

Buffer: In 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Target Details for CD80

Target: CD80

Alternative Name: T-lymphocyte activation antigen CD80

Background:

Target Description: T cell proliferation and lymphokine production are triggered by occupation of the TCR by antigen, followed by a costimulatory signal that is delivered by a ligand expressed on antigen presenting cells. The B7-related cell surface proteins CD80 (B7-1) and CD86 (B7-2) are expressed on antigen presenting cells bind the homologous T cell receptors CTLA-4 (cytotoxic T lymphocyte-associated protein-4) and CD28 and trigger costimulatory signals for optimal T cell activation. CTLA-4 shares 31 % overall amino acid identity with CD28 and it has been proposed that CD28 and CTLA-4 are functionally redundant. SLAM is a novel receptor on T cells that, when engaged, potentiates T cell expansion in a CD28-independent manner. B7, also designated BB1, is another ligand or counter receptor for CD28 and CTLA-4 that is expressed on the antigen-presenting cell.

Gene Symbol: CD80///CD28LG///CD28LG1///LAB7

Gene ID: 941

UniProt: P33681

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints