Integrin beta 2 antibody (ITGB2)

Details for Product anti-ITGB2 Antibody No. ABIN6297676
Antigen
  • CD18
  • LAD
  • LCAMB
  • LFA-1
  • MAC-1
  • MF17
  • MFI7
  • 2E6
  • AI528527
  • Cd18
  • Lfa1
  • ITGB2
  • itgb2
  • itgb2-a
  • itgb2-b
  • integrin subunit beta 2
  • integrin beta 2
  • integrin subunit beta 2 S homeolog
  • ITGB2
  • Itgb2
  • itgb2.S
Reactivity
Human
445
176
111
21
19
9
6
4
4
3
3
3
3
2
2
Host
Mouse
282
186
102
2
2
1
Clonality
Monoclonal
Conjugate
This Integrin beta 2 antibody is un-conjugated
74
61
44
22
12
8
8
6
5
5
5
5
5
3
3
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Functional Studies (Func), Immunofluorescence (IF)
344
243
148
130
90
62
57
53
39
39
13
10
9
7
6
1
1
1
1
1
Options
Purpose Mouse anti-Human CD18 Antibody [Sodium Azide Free]
Immunogen Stimulated human leukocytes were used as the immunogen for the CD18 antibody.
Specificity Cell surface
Purification Stimulated human leukocytes were used as the immunogen for the CD18 antibody.
Plasmids, Primers & others Plasmids, Primers & others Integrin beta 2 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name Integrin beta-2 (ITGB2 Antibody Abstract)
Background

Target Description: It recognizes a transmembrane glycoprotein of 95 kDa, identified as CD18 or integrin -2 (Workshop III). It complexes non-covalently with either L, M, or X integrin (CD11a, b, or c) to form the heterodimers, LFA-1, Mac-1, and p150,95, respectively. LFA-1 is the receptor for three members of the Ig supergene family of proteins, ICAM-1 (CD54), ICAM-2 (CD102), and Mac-1 and p150,95 bind to ICAM-1, fibrinogen, and iC3b. ICAM-3 (CD50). CD18/CD11 heterodimeric molecules are involved with cell/cell and cell/extracellular adhesion in immune and inflammatory responses. This mAb blocks these cellular interactions.

Gene Symbol: ITGB2///CD18///MFI7

Gene ID 3689
UniProt P05107
Pathways NF-kappaB Signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation
Application Notes Functional Activity (Order SAF formulation)
Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 0.5-1 μg/mL
Restrictions For Research Use only
Buffer In 1X PBS, BSA free, sodium azide free
Preservative Azide free
Storage 4 °C,-20 °C
Storage Comment 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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