CD46 antibody

Catalog No. ABIN6297689

The Mouse Monoclonal anti-CD46 antibody has been validated for FACS and IF. It is suitable to detect CD46 in samples from Human and Baboon.

Quick Overview for CD46 antibody (ABIN6297689)

Target: CD46

Reactivity: Human, Baboon

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD46 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunofluorescence (IF)

Product Details anti-CD46 Antibody

Purpose: Mouse anti-Human/Baboon CD46 Antibody [Sodium Azide Free]

Specificity: Cell surface

Purification: Stimulated human leukocytes were used as the immunogen for the CD46 antibody.

Immunogen: Stimulated human leukocytes were used as the immunogen for the CD46 antibody.

Application Details

Application Notes: Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: In 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Target Details for CD46

Target: CD46

Alternative Name: Membrane cofactor protein

Background:

Target Description: Recognizes a protein of 52 kDa-58 kDa, identified as CD46 (also known as membrane cofactor protein, MCP). Its epitope is located on the four immunogenic short consensus repeat (SCR) domains at N-terminus of the protein. CD46 exists as many isoforms in a variety of tissues. It is strongly expressed on salivary gland ducts and kidney ducts, moderately on lymphocytes and endothelium, and weakly on interstitial tissues and muscle cells, but not on erythrocytes. CD46 functions as a C3b/C4b-binding glycoprotein that inhibits complement activation on host cells. It also serves as a measles virus receptor, an adherence factor for group A Streptococcus pyogenes, and a cellular pilus receptor for pathogenic Neisseria.

Gene Symbol: CD46///MCP///MIC10

Gene ID: 4179

UniProt: P15529

Pathways: Regulation of Actin Filament Polymerization