CD44 antibody

Catalog No. ABIN6297698

The Mouse Monoclonal anti-CD44 antibody has been validated for IHC. It is suitable to detect CD44 in samples from Human, Baboon and Green Monkey.

Quick Overview for CD44 antibody (ABIN6297698)

Target: CD44

Reactivity: Human, Baboon, Green Monkey

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD44 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-CD44 Antibody

Purpose: Mouse anti-Human/Baboon/Green Monkey HCAM Antibody CD44 [IHC only]

Specificity: Cell surface

Purification: Stimulated human leukocytes were used as the immunogen for this CD44 / HCAM antibody.

Immunogen: Stimulated human leukocytes were used as the immunogen for this CD44 / HCAM antibody.

Application Details

Application Notes: Prediluted format : incubate for 30 min at RT (2)

Restrictions: For Research Use only

Handling

Buffer: Prediluted in 1X PBS ( pH 7.4) with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, For IHC use only

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Target Details for CD44

Target: CD44

Alternative Name: CD44 antigen

Background:

Target Description: This antibody recognizes a cell surface glycoprotein of 80-95 kDa, called CD44, or HCAM, on lymphocytes, monocytes, and granulocytes (Leucocyte Typing Workshop V). Its epitope is resistant to digestion by trypsin and chymotrypsin. The CD44 family of glycoproteins exists in a number of variant isoforms, the most common being the standard 85-95 kDa or hematopoietic variant (CD44-s). Higher molecular weight isoforms are described in epithelial cells (CD44-v), which are believed to function in intercellular adhesion and stromal binding. HCAM antibody immunostaining is commonly used for the discrimination of urothelial transitional cell carcinoma in-situ from non-neoplastic changes in the urothelium.

Gene Symbol: CD44///LHR///MDU2///MDU3///MIC4

Gene ID: 960

UniProt: P16070

Pathways: Glycosaminoglycan Metabolic Process, Autophagy, Negative Regulation of intrinsic apoptotic Signaling