VEGFC antibody

Catalog No. ABIN650694

Cited in 5+ publications. The Rabbit Polyclonal anti-VEGFC antibody (Clone RB22679) (ABIN650694) specifically detects VEGFC in WB and FACS. The antibody is reactive with Human samples.

Quick Overview for VEGFC antibody (ABIN650694)

Target: VEGFC (Vascular Endothelial Growth Factor C (VEGFC))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This VEGFC antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Clone: RB22679

Product Details anti-VEGFC Antibody

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This VEGFC antibody is generated from rabbits immunized with VEGFC recombinant protein.

Isotype: IgG

Application Details

Application Notes: WB: 1:2000. WB: 1:2000. FC: 1:25

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-VEGFC antibody (ABIN650694)

Dai, Liu, Liu, Zhang, Wang, Jin, Qian, Wang, Zhao, Wu, Xiong, Chang, Sun, Yang, Hoffman, Liu: "Anti-metastatic Efficacy of Traditional Chinese Medicine (TCM) Ginsenoside Conjugated to a VEFGR-3 Antibody on Human Gastric Cancer in an Orthotopic Mouse Model." in: Anticancer research, Vol. 37, Issue 3, pp. 979-986, (2017) (PubMed).

Zhao, Hou, Hou, Zhu: "Concurrent Expression of VEGF-C and Neuropilin-2 Is Correlated with Poor Prognosis in Glioblastoma." in: The Tohoku journal of experimental medicine, Vol. 238, Issue 2, pp. 85-91, (2016) (PubMed).

Yang, Wang, Dong, Shen, Guo, Liu, Liu, Zhang, Li, Sun: "Progranulin promotes colorectal cancer proliferation and angiogenesis through TNFR2/Akt and ERK signaling pathways." in: American journal of cancer research, Vol. 5, Issue 10, pp. 3085-97, (2015) (PubMed).

Shi, Yang, Shen, Yang, Xu, Qiu, Sun, Zhang, Wang, Zhu, Qin, Tang, Fan, Zhou: "High expression of Dickkopf-related protein 1 is related to lymphatic metastasis and indicates poor prognosis in intrahepatic cholangiocarcinoma patients after surgery." in: Cancer, Vol. 119, Issue 5, pp. 993-1003, (2013) (PubMed).

Hirata, Hinoda, Ueno, Shahryari, Tabatabai, Dahiya: "MicroRNA-1826 targets VEGFC, beta-catenin (CTNNB1) and MEK1 (MAP2K1) in human bladder cancer." in: Carcinogenesis, Vol. 33, Issue 1, pp. 41-8, (2011) (PubMed).

Target Details for VEGFC

Target: VEGFC (Vascular Endothelial Growth Factor C (VEGFC))

Alternative Name: VEGFC

Background: VEGF3 is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor D.

Molecular Weight: 46883

Gene ID: 7424

NCBI Accession: NP_005420

UniProt: P49767

Pathways: RTK Signaling, Signaling Events mediated by VEGFR1 and VEGFR2