Pyruvate Dehydrogenase E1 alpha (pSer232) antibody

Catalog No. ABIN650896

This Rabbit Polyclonal antibody specifically detects Pyruvate Dehydrogenase E1 alpha in WB and DB. It exhibits reactivity toward Human. It has been mentioned in 2+ publications

Quick Overview for Pyruvate Dehydrogenase E1 alpha (pSer232) antibody (ABIN650896)

Target: Pyruvate Dehydrogenase E1 alpha

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), Dot Blot (DB)

Clone: RB29473

Product Details

Binding Specificity: pSer232

Predicted Reactivity: B, Pr, M, Pig, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PDHE1A Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S232 of human PDHE1A.

Isotype: IgG

Application Details

Application Notes: WB: 1:500. WB: 1:5000. DB: 1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References

Agnihotri, Golbourn, Huang, Remke, Younger, Cairns, Chalil, Smith, Krumholtz, Mackenzie, Rakopoulos, Ramaswamy, Taccone, Mischel, Fuller, Hawkins, Stanford, Taylor, Zadeh, Rutka: "PINK1 Is a Negative Regulator of Growth and the Warburg Effect in Glioblastoma." in: Cancer research, Vol. 76, Issue 16, pp. 4708-19, (2017) (PubMed).

Sun, Xie, Liu, Zhao, Wu, Zhang, Lv, Tang, Jin, Jiang, Tan, Ding, Luo, Li, Huang, Geng: "JX06 Selectively Inhibits Pyruvate Dehydrogenase Kinase PDK1 by a Covalent Cysteine Modification." in: Cancer research, Vol. 75, Issue 22, pp. 4923-36, (2016) (PubMed).

Target Details

Target: Pyruvate Dehydrogenase E1 alpha

Alternative Name: PDHE1A

Molecular Weight: 43296

NCBI Accession: NP_000275, NP_001166925, NP_001166926, NP_001166927

UniProt: P08559