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PINK1 antibody (C-Term)

The Rabbit Polyclonal anti-PINK1 antibody has been validated for WB. It is suitable to detect PINK1 in samples from Human and Mouse. There is 1 publication available.
Catalog No. ABIN652208

Quick Overview for PINK1 antibody (C-Term) (ABIN652208)

Target

See all PINK1 Antibodies
PINK1 (PTEN Induced Putative Kinase 1 (PINK1))

Reactivity

  • 89
  • 28
  • 10
  • 2
  • 2
  • 1
  • 1
  • 1
Human, Mouse

Host

  • 57
  • 44
  • 1
Rabbit

Clonality

  • 61
  • 43
Polyclonal

Conjugate

  • 58
  • 8
  • 6
  • 5
  • 4
  • 4
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This PINK1 antibody is un-conjugated

Application

  • 77
  • 62
  • 44
  • 28
  • 20
  • 8
  • 6
  • 6
  • 5
  • 3
  • 1
  • 1
Western Blotting (WB)

Clone

RB6517
  • Binding Specificity

    • 28
    • 7
    • 7
    • 6
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 493-526, C-Term

    Purification

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    Immunogen

    This Park6(PINK1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 493-526 amino acids from the C-terminal region of human Park6(PINK1).

    Isotype

    Ig Fraction
  • Application Notes

    WB: 1:1000

    Restrictions

    For Research Use only
  • Format

    Liquid

    Buffer

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    4 °C,-20 °C

    Storage Comment

    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

    Expiry Date

    6 months
  • Berthier, Jiménez-Sáinz, Pulido: "PINK1 regulates histone H3 trimethylation and gene expression by interaction with the polycomb protein EED/WAIT1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, Issue 36, pp. 14729-34, (2013) (PubMed).

  • Target

    PINK1 (PTEN Induced Putative Kinase 1 (PINK1))

    Alternative Name

    Park6 (PINK1)

    Background

    Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson disease identified to date. Defects in PINK1 are the cause of autosomal recessive early-onset Parkinson's disease 6 (PARK6). Six novel pathogenic PINK1 mutations suggest that PINK1 may be the second most common causative gene next to parkin in parkinsonism with the recessive mode of inheritance. Strong evidence indicates that, although important in mendelian forms of Parkinson's disease (PD), PINK1 does not influence the cause of sporadic nonmendelian forms of PD.

    Molecular Weight

    62769

    Gene ID

    65018

    NCBI Accession

    NP_115785

    UniProt

    Q9BXM7

    Pathways

    Autophagy
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