SREBF chaperone antibody (AA 604-632)

Catalog No. ABIN652508

Product Details anti-SREBF chaperone Antibody

Target: SREBF chaperone (SCAP)

Binding Specificity: AA 604-632

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SREBF chaperone antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunofluorescence (IF)

Predicted Reactivity: B, Pig

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This SCAP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 604-632 amino acids from the Central region of human SCAP.

Clone: RB22508

Isotype: Ig Fraction

Application Details

Application Notes: IF: 1:100. WB: 1:2000. WB: 1:2000. WB: 1:1000. IHC-P: 1:50~100. FC: 1:25. FC: 1:25

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-SREBF chaperone antibody (ABIN652508)

Takashima, Saitoh, Funabashi, Hirose, Yagi, Nozaki, Sato, Shin, Nakayama: "COPI-mediated retrieval of SCAP is crucial for regulating lipogenesis under basal and sterol-deficient conditions." in: Journal of cell science, Vol. 128, Issue 15, pp. 2805-15, (2015) (PubMed).

Target Details for SREBF chaperone

Target: SREBF chaperone (SCAP)

Alternative Name: SCAP (SCAP Products)

Synonyms: 9530044G19 antibody, mKIAA0199 antibody, SREBF chaperone antibody, SREBF chaperone S homeolog antibody, SCAP antibody, Scap antibody, scap.S antibody

Background: SCAP is a protein with a sterol sensing domain(SSD) and seven WD domains. In the presence of cholesterol, this protein binds to sterol regulatory element binding proteins (SREBPs) and mediates their transport from the ER to the Golgi. The SREBPs are then proteolytically cleaved and regulate sterol biosynthesis.

Molecular Weight: 139729

Gene ID: 22937

NCBI Accession: NP_036367

UniProt: Q12770

Pathways: SARS-CoV-2 Protein Interactome