Gephyrin antibody (AA 437-466)

Catalog No. ABIN653742

Product Details anti-Gephyrin Antibody

Target: Gephyrin (GPHN)

Binding Specificity: AA 437-466

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Gephyrin antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Predicted Reactivity: C, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This GPHN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 437-466 amino acids from the Central region of human GPHN.

Clone: RB24625

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for Gephyrin

Target: Gephyrin (GPHN)

Alternative Name: GPHN (GPHN Products)

Synonyms: 5730552E08Rik antibody, AI662856 antibody, BC027112 antibody, C230040D23 antibody, GPH antibody, GPHRYN antibody, geph antibody, Geph antibody, GPHN antibody, GEPH antibody, HKPX1 antibody, gpgb1 antibody, DKFZp459M0825 antibody, gephyrin antibody, gephyrin L homeolog antibody, gephyrin a antibody, Gphn antibody, GPHN antibody, gphn.L antibody, gphna antibody, PTRG_08978 antibody, VDBG_00775 antibody, Tsp_03043 antibody, gphn antibody

Background: GPHN encodes a neuronal assembly protein that anchors inhibitory neurotransmitter receptors to the postsynaptic cytoskeleton via high affinity binding to a receptor subunit domain and tubulin dimers. In nonneuronal tissues, the encoded protein is also required for molybdenum cofactor biosynthesis. Mutations in this gene may be associated with the neurological condition hyperplexia and also lead to molybdenum cofactor deficiency.

Molecular Weight: 79748

Gene ID: 10243

NCBI Accession: NP_001019389, NP_065857

UniProt: Q9NQX3

Pathways: Synaptic Membrane, Skeletal Muscle Fiber Development