RENT2/UPF2 antibody (AA 630-656)

Catalog No. ABIN654649

This Rabbit Polyclonal antibody specifically detects RENT2/UPF2 in WB and FACS. It exhibits reactivity toward Human.

Quick Overview for RENT2/UPF2 antibody (AA 630-656) (ABIN654649)

Target: RENT2/UPF2 (UPF2) (UPF2 Regulator of Nonsense Transcripts 2 (UPF2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RENT2/UPF2 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Clone: RB21963

Product Details anti-RENT2/UPF2 Antibody

Binding Specificity: AA 630-656

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This UPF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 630-656 amino acids from the Central region of human UPF2.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. FC: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for RENT2/UPF2

Target: RENT2/UPF2 (UPF2) (UPF2 Regulator of Nonsense Transcripts 2 (UPF2))

Alternative Name: UPF2

Background: UPF2 is a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p.

Molecular Weight: 147810

Gene ID: 26019

NCBI Accession: NP_056357, NP_542166

UniProt: Q9HAU5