RENT2/UPF2 antibody (AA 1153-1272)

Catalog No. ABIN7167643

Product Details anti-RENT2/UPF2 Antibody

Target: RENT2/UPF2 (UPF2) (UPF2 Regulator of Nonsense Transcripts 2 (UPF2))

Binding Specificity: AA 1153-1272

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RENT2/UPF2 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Regulator of nonsense transcripts 2 protein (1153-1272AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for RENT2/UPF2

Target: RENT2/UPF2 (UPF2) (UPF2 Regulator of Nonsense Transcripts 2 (UPF2))

Alternative Name: UPF2 (UPF2 Products)

Synonyms: HUPF2 antibody, RENT2 antibody, smg-3 antibody, UPF2, regulator of nonsense mediated mRNA decay antibody, UPF2 regulator of nonsense transcripts homolog (yeast) antibody, UPF2 antibody, Upf2 antibody, upf2 antibody

Background:

Background: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3B stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA.

Aliases: DKFZp434D222 antibody, hUpf2 antibody, KIAA1408 antibody, MGC138834 antibody, MGC138835 antibody, Nonsense mRNA reducing factor 2 antibody, Regulator of nonsense transcripts 2 antibody, RENT2 antibody, RENT2_HUMAN antibody, Smg 3 antibody, Smg 3 homolog nonsense mediated mRNA decay factor antibody, Up-frameshift suppressor 2 homolog antibody, UPF2 antibody, UPF2 regulator of nonsense transcripts homolog antibody, UROC1 antibody, Urocanate hydratase antibody, Yeast Upf2p homolog antibody

UniProt: Q9HAU5