NRP2 antibody (C-Term)

Catalog No. ABIN655525

Product Details anti-NRP2 Antibody

Target: NRP2 (Neuropilin 2 (NRP2))

Binding Specificity: AA 798-827, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NRP2 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Neuropilin-2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 798-827 amino acids from the C-terminal region of human Neuropilin-2.

Clone: RB19998

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-NRP2 antibody (ABIN655525)

Zhao, Fu, Yao, Jia, Zhang, Li, Dong, Gao, Liu, Chen, Zhou: "Label-free quantitative proteomic analysis of benzo(a)pyrene-transformed 16HBE cells serum-free culture supernatant and xenografted nude mice sera." in: Chemico-biological interactions, Vol. 245, pp. 39-49, (2016) (PubMed).

Davare, Lal, Peckham, Prajapati, Gultekin, Rubin, Keller: "Secreted meningeal chemokines, but not VEGFA, modulate the migratory properties of medulloblastoma cells." in: Biochemical and biophysical research communications, Vol. 450, Issue 1, pp. 555-60, (2014) (PubMed).

Target Details for NRP2

Target: NRP2 (Neuropilin 2 (NRP2))

Alternative Name: Neuropilin-2 (NRP2 Products)

Background: This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene.

Molecular Weight: 104831

Gene ID: 8828

NCBI Accession: NP_003863, NP_061004, NP_957716, NP_957718, NP_957719, NP_958436

UniProt: O60462

Pathways: Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals