PITRM1 antibody (AA 490-518)

Catalog No. ABIN656324

The Rabbit Polyclonal anti-PITRM1 antibody has been validated for WB. It is suitable to detect PITRM1 in samples from Human.

Quick Overview for PITRM1 antibody (AA 490-518) (ABIN656324)

Target: PITRM1 (Pitrilysin Metallopeptidase 1 (PITRM1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PITRM1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB31351

Product Details anti-PITRM1 Antibody

Binding Specificity: AA 490-518

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PITRM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 490-518 amino acids from the Central region of human PITRM1.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: PITRM1 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.

Expiry Date: 6 months

Target Details for PITRM1

Target: PITRM1 (Pitrilysin Metallopeptidase 1 (PITRM1))

Alternative Name: PITRM1

Background: ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides. Specific for peptides in the range of 10 to 65 residues. Able to degrade amyloid beta A4 (APP) protein when it accumulates in mitochondrion, suggesting a link with Alzheimer disease. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference.

Molecular Weight: 117413

Gene ID: 10531

NCBI Accession: NP_001229236, NP_001229238, NP_055704

UniProt: Q5JRX3

Pathways: PI3K-Akt Signaling, SARS-CoV-2 Protein Interactome