beta Amyloid antibody

Catalog No. ABIN6566498

The Rabbit Polyclonal anti-beta Amyloid antibody has been validated for WB and IHC. It is suitable to detect beta Amyloid in samples from Human.

Quick Overview for beta Amyloid antibody (ABIN6566498)

Target: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This beta Amyloid antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-beta Amyloid Antibody

Purification: Affinity purification

Immunogen: Recombinant protein of human APP

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000 IHC 1:50 - 1:200

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for beta Amyloid

Target: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Alternative Name: beta Amyloid

Background:

Synonyms: A4 amyloid protein,A4,AAA,ABETA,ABPP,AD1,AICD-50,AICD-57,AICD-59,AID(50),AID(57),AID(59),Alzheimer disease amyloid protein,Amyloid beta (A4) precursor protein,Amyloid beta A4 protein,Amyloid beta protein,Amyloid intracellular domain 50,Amyloid intracellular domain 57,Amyloid intracellular domain 59,Amyloid precursor protein,APP,APPI,Beta amyloid peptide,Beta-amyloid precursor protein,Beta-APP40,Beta-APP42,C31,Cerebral vascular amyloid peptide,CTFgamma,CVAP,Gamma-CTF(50),Gamma-CTF(57),Gamma-CTF(59),peptidase nexin II,PN 2,PN II,PN-II,PN2,PreA4,Protease nexin II,Protease nexin-II,S-APP-alpha,S-APP-beta

Background: This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

Molecular Weight:

Observed_MW: 110kDa

Calculated_MW: 34kDa/72-86kDa

Gene ID: 351

UniProt: P05067

Pathways: Inflammasome