LEF1 antibody

Catalog No. ABIN6566691

This anti-LEF1 antibody is a Rabbit Polyclonal antibody detecting LEF1 in WB. Suitable for Human and Mouse.

Quick Overview for LEF1 antibody (ABIN6566691)

Target: LEF1 (Lymphoid Enhancer-Binding Factor 1 (LEF1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LEF1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-LEF1 Antibody

Purification: Affinity purification

Immunogen: Recombinant Protein of human LEF1

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for LEF1

Target: LEF1 (Lymphoid Enhancer-Binding Factor 1 (LEF1))

Alternative Name: LEF1

Background:

Synonyms: DKFZp586H0919,FLJ46390,LEF 1,LEF-1,Lef1,LEF1,Lymphoid enhancer binding factor 1,Lymphoid enhancer-binding factor 1,T cell specific transcription factor 1 alpha,T cell-specific transcription factor 1-alpha,TCF 1 alpha,TCF1 alpha,TCF1-alpha,TCF10,TCF1alpha,TCF7L3,Transcription factor T cell specific 1 alpha

Background: This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants.

Molecular Weight:

Observed_MW: 40kDa

Calculated_MW: 23kDa/31kDa/34kDa/35kDa/41kDa/42kDa/44kDa

Gene ID: 51176

UniProt: Q9UJU2

Pathways: WNT Signaling, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Hormone Metabolic Process, Nuclear Hormone Receptor Binding, Chromatin Binding