NACA antibody

Catalog No. ABIN6566781

The Rabbit Polyclonal anti-NACA antibody has been validated for WB. It is suitable to detect NACA in samples from Human, Mouse and Rat.

Quick Overview for NACA antibody (ABIN6566781)

Target: NACA (NACa1) (Nascent Polypeptide Associated Complex alpha 1 (NACa1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NACA antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-NACA Antibody

Purification: Affinity purification

Immunogen: Recombinant protein of human NACA

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for NACA

Target: NACA (NACa1) (Nascent Polypeptide Associated Complex alpha 1 (NACa1))

Alternative Name: NACA

Background:

Synonyms: Alpha NAC,Alpha-NAC,Hom s 2.02,HSD48 ,MGC117224,NAC-alpha,naca,NACA/1.9.2,NACA,NACA1,Nascent polypeptide associated complex alpha polypeptide,Nascent polypeptide associated complex alpha subunit,Nascent polypeptide associated complex subunit alpha,Nascent polypeptide-associated complex subunit alpha

Background: This gene encodes a protein that associates with basic transcription factor 3 (BTF3) to form the nascent polypeptide-associated complex (NAC). This complex binds to nascent proteins that lack a signal peptide motif as they emerge from the ribosome, blocking interaction with the signal recognition particle (SRP) and preventing mistranslocation to the endoplasmic reticulum. This protein is an IgE autoantigen in atopic dermatitis patients. Alternative splicing results in multiple transcript variants, but the full length nature of some of these variants, including those encoding very large proteins, has not been determined. There are multiple pseudogenes of this gene on different chromosomes.

Molecular Weight:

Observed_MW: 37kDa, 39kDa

Calculated_MW: 23kDa/94kDa/205kDa

Gene ID: 4666

UniProt: Q13765

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development