HLA-C antibody

Catalog No. ABIN6566785

The Rabbit Polyclonal anti-HLA-C antibody (ABIN6566785) specifically detects HLA-C in WB. The antibody is reactive with Human and Mouse samples.

Quick Overview for HLA-C antibody (ABIN6566785)

Target: HLA-C (Major Histocompatibility Complex Class I C (HLA-C))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HLA-C antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-HLA-C Antibody

Purification: Affinity purification

Immunogen: Recombinant protein of human HLA-C

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for HLA-C

Target: HLA-C (Major Histocompatibility Complex Class I C (HLA-C))

Alternative Name: HLA-C

Background:

Synonyms: 1C07,Cw-7 alpha chain,D6S204,HLA class I histocompatibility antigen,HLA class I histocompatibility antigen, C alpha chain,HLA class I histocompatibility antigen, Cw-1 alpha chain,HLA-C,HLA-C histocompatibility type,HLA-Cw,HLA-JY3,HLAC,HLC-C,human leukocyte antigen-C alpha chain,major histocompatibility antigen HLA-C,major histocompatibility complex, class I, C ,MHC class I antigen,MHC class I antigen Cw 1,MHC class I antigen Cw*7,MHC class I antigen heavy chain HLA-C,PSORS1

Background: HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described

Molecular Weight:

Observed_MW: 41kDa

Calculated_MW: 41kDa

Gene ID: 3107

UniProt: P10321

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Human Leukocyte Antigen (HLA) in Adaptive Immune Response