POLE2 antibody

Catalog No. ABIN6567661

This Rabbit Polyclonal antibody specifically detects POLE2 in WB. It exhibits reactivity toward Human and Mouse.

Quick Overview for POLE2 antibody (ABIN6567661)

Target: POLE2 (Polymerase (DNA Directed), epsilon 2 (p59 Subunit) (POLE2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This POLE2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-POLE2 Antibody

Purification: Affinity purification

Immunogen: Recombinant protein of human POLE2

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for POLE2

Target: POLE2 (Polymerase (DNA Directed), epsilon 2 (p59 Subunit) (POLE2))

Alternative Name: DNA pol epsilon B

Background:

Synonyms: DNA polymerase epsilon subunit 2,DNA polymerase epsilon subunit B,DNA polymerase II subunit 2,DPE 2,DPE2,DPOE2,POLE 2,POLE2,Polymerase (DNA directed) epsilon 2 (p59 subunit),Polymerase (DNA directed) epsilon 2,polymerase (DNA directed),epsilon 2,accessory subunit,Polymerase,DNA,epsilon-2

Background: DNA polymerase epsilon, which is involved in DNA repair and replication, is composed of a large catalytic subunit and a small accessory subunit. The protein encoded by this gene represents the small subunit (B). Defects in this gene have been linked to colorectal cancer and to combined immunodeficiency.

Molecular Weight:

Observed_MW: 59kDa

Calculated_MW: 56kDa/59kDa

Gene ID: 5427

UniProt: P56282

Pathways: Telomere Maintenance, DNA Damage Repair, Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA