RENT2/UPF2 antibody

Catalog No. ABIN6570914

The Rabbit Polyclonal anti-RENT2/UPF2 antibody has been validated for WB and IHC. It is suitable to detect RENT2/UPF2 in samples from Human, Rat and Mouse.

Quick Overview for RENT2/UPF2 antibody (ABIN6570914)

Target: RENT2/UPF2 (UPF2) (UPF2 Regulator of Nonsense Transcripts 2 (UPF2))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RENT2/UPF2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-RENT2/UPF2 Antibody

Purification: Affinity purification

Immunogen: Recombinant protein of human UPF2

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000 IHC 1:50 - 1:200

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for RENT2/UPF2

Target: RENT2/UPF2 (UPF2) (UPF2 Regulator of Nonsense Transcripts 2 (UPF2))

Alternative Name: UPF2

Background:

Synonyms: DKFZp434D222,hUpf2,KIAA1408,MGC138834,MGC138835,Nonsense mRNA reducing factor 2,Regulator of nonsense transcripts 2,RENT2,RENT2,Smg 3,Smg 3 homolog nonsense mediated mRNA decay factor,Up-frameshift suppressor 2 homolog,UPF2,UPF2 regulator of nonsense transcripts homolog,UROC1,Urocanate hydratase,Yeast Upf2p homolog

Background: This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene, both variants encode the same protein.

Molecular Weight:

Observed_MW: 148kDa

Calculated_MW: 66kDa/147kDa

Gene ID: 26019

UniProt: Q9HAU5