XPC antibody

Catalog No. ABIN5964337

The Rabbit Polyclonal anti-XPC antibody (ABIN5964337) specifically detects XPC in IHC. The antibody is reactive with Human samples.

Quick Overview for XPC antibody (ABIN5964337)

Target: XPC (Xeroderma Pigmentosum, Complementation Group C (XPC))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This XPC antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-XPC Antibody

Purification: Affinity purification

Immunogen: Recombinant fusion protein of human XPC (NP_004619.3).

Isotype: IgG

Application Details

Application Notes: IHC 1:50-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for XPC

Target: XPC (Xeroderma Pigmentosum, Complementation Group C (XPC))

Alternative Name: XPC

Background: This gene encodes a component of the nucleotide excision repair (NER) pathway. There are multiple components involved in the NER pathway, including Xeroderma pigmentosum (XP) A-G and V, Cockayne syndrome (CS) A and B, and trichothiodystrophy (TTD) group A, etc. This component, XPC, plays an important role in the early steps of global genome NER, especially in damage recognition, open complex formation, and repair protein complex formation. Mutations in this gene or some other NER components result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene.

Molecular Weight:

Observed_MW: 130kDa

Calculated_MW: 15kDa/101kDa/105kDa

Gene ID: 7508

UniProt: Q01831

Pathways: p53 Signaling, DNA Damage Repair