EPH Receptor B2 antibody

Catalog No. ABIN6572022

Product Details anti-EPH Receptor B2 Antibody

Target: EPH Receptor B2 (EPHB2)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EPH Receptor B2 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogen: Recombinant protein of human EPHB2

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for EPH Receptor B2

Target: EPH Receptor B2 (EPHB2)

Alternative Name: EPHB2 (EPHB2 Products)

Background:

Synonyms: cek5,Developmentally regulated EPH related tyrosine kinase,DRT,EK5,ELK related protein tyrosine kinase,Eph receptor B2,EPH tyrosine kinase 3,EPH-like kinase 5,EPHB2,EPHB2,Ephrin type B receptor 2,Ephrin type-B receptor 2,EPHT 3,ERK,ETECK,hEK5,Nuk,Prkm 5,Receptor protein tyrosine kinase HEK 5,Renal carcinoma antigen NY-REN-47,Sek 3,Tyro 5,Tyrosine protein kinase receptor CEK 5,Tyrosine protein kinase receptor EPH 3,Tyrosine protein kinase receptor QEK 5,Tyrosine-protein kinase receptor EPH-3,Tyrosine-protein kinase TYRO5

Background: This gene encodes a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors are composed of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. They bind ligands called ephrins and are involved in diverse cellular processes including motility, division, and differentiation. A distinguishing characteristic of Eph-ephrin signaling is that both receptors and ligands are competent to transduce a signaling cascade, resulting in bidirectional signaling. This protein belongs to a subgroup of the Eph receptors called EphB. Proteins of this subgroup are distinguished from other members of the family by sequence homology and preferential binding affinity for membrane-bound ephrin-B ligands. Allelic variants are associated with prostate and brain cancer susceptibility. Alternative splicing results in multiple transcript variants.

Molecular Weight:

Observed_MW: 117kDa

Calculated_MW: 109kDa/110kDa/117kDa

Gene ID: 2048

UniProt: P29323

Pathways: RTK Signaling, Regulation of long-term Neuronal Synaptic Plasticity, S100 Proteins