MUC1 antibody (C-Term)

Catalog No. ABIN657546

This anti-MUC1 antibody is a Rabbit Polyclonal antibody detecting MUC1 in WB and IHC (p). Suitable for Human. This Primary Antibody has been cited in 1 publication.

Quick Overview for MUC1 antibody (C-Term) (ABIN657546)

Target: MUC1 (Mucin 1 (MUC1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MUC1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB33144

Product Details anti-MUC1 Antibody

Binding Specificity: AA 1176-1205, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This MUC1/EMA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1176-1205 amino acids from the C-terminal region of human MUC1/EMA.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: MUC1/EMA Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.

Expiry Date: 6 months

References for anti-MUC1 antibody (ABIN657546)

Liu, Meng, Liu, Li, Wu, Zhang, E: "Hepatic epithelioid angiomyolipoma is a rare and potentially severe but treatable tumor: A report of three cases and review of the literature." in: Oncology letters, Vol. 11, Issue 6, pp. 3669-3675, (2016) (PubMed).

Target Details for MUC1

Target: MUC1 (Mucin 1 (MUC1))

Alternative Name: MUC1/EMA

Background: This gene is a member of the mucin family and encodes a membrane bound, glycosylated phosphoprotein. The protein is anchored to the apical surface of many epithelia by a transmembrane domain, with the degree of glycosylation varying with cell type. It also includes a 20 aa variable number tandem repeat (VNTR) domain, with the number of repeats varying from 20 to 120 in different individuals. The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. Multiple alternatively spliced transcript variants that encode different isoforms of this gene have been reported, but the full-length nature of only some has been determined. [provided by RefSeq].

Molecular Weight: 122102

Gene ID: 4582

NCBI Accession: NP_001018016, NP_001018017, NP_001037855, NP_001037856, NP_001037857, NP_001037858, NP_001191214, NP_001191215, NP_001191216, NP_001191217, NP_001191218, NP_001191219, NP_001191220, NP_00

UniProt: P15941

Pathways: Negative Regulation of intrinsic apoptotic Signaling