MCL-1 antibody (AA 217-245)

Catalog No. ABIN657627

The Rabbit Polyclonal anti-MCL-1 antibody (Clone RB33638) (ABIN657627) specifically detects MCL-1 in WB and IHC (p). The antibody is reactive with Human samples.

Quick Overview for MCL-1 antibody (AA 217-245) (ABIN657627)

Target: MCL-1 (MCL1) (Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MCL-1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB33638

Product Details anti-MCL-1 Antibody

Binding Specificity: AA 217-245

Predicted Reactivity: Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This MCL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 217-245 amino acids from the Central region of human MCL1.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: MCL1 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.

Expiry Date: 6 months

Target Details for MCL-1

Target: MCL-1 (MCL1) (Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1))

Alternative Name: MCL1

Background: This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing.

Molecular Weight: 37337

Gene ID: 4170

NCBI Accession: NP_001184249, NP_068779, NP_877495

UniProt: Q07820

Pathways: MAPK Signaling