JMJD2D antibody (AA 337-359)

Catalog No. ABIN6579170

The Rabbit Polyclonal anti-JMJD2D antibody is suitable to detect JMJD2D in samples from Human. It has been validated for WB.

Quick Overview for JMJD2D antibody (AA 337-359) (ABIN6579170)

Target: JMJD2D (KDM4D) (Lysine (K)-Specific Demethylase 4D (KDM4D))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This JMJD2D antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-JMJD2D Antibody

Binding Specificity: AA 337-359

Purpose: JMJD2D antibody (pAb)

Purification: Affinity Purified

Immunogen: This JMJD2D antibody was raised against a peptide corresponding to amino acids 337-359 of human JMJD2D.

Isotype: IgG

Application Details

Application Notes: WB: 1:500 - 1:2,000 dilution

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified rabbit IgG in PBS with 30 % glycerol and 0.035 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Storage: -20 °C

Storage Comment: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Expiry Date: 24 months

Target Details for JMJD2D

Target: JMJD2D (KDM4D) (Lysine (K)-Specific Demethylase 4D (KDM4D))

Alternative Name: JMJD2D

Background: JMJD2D (KDM4D) is a histone demethylase located in the nucleus that specifically demethylates Lysine 9 of Histone H3, thereby playing a central role in the histone code. JMJD2D (KDM4D) demethylates both di- and trimethylated histone H3 Lys 9, while it has no activity on monomethylated residues. The demethylation reaction of the Lys residue generates formaldehyde and succinate as a by product. In addition, JMJD2D forms a complex with the ligand-bound form of the Androgen Receptor (AR) and, through this interaction, activates AR expression. Overexpression of AR is associated with prostate cancer, suggesting that, via its ability to upregulate AR, JMJD2D (KDM4D) may be involved in carcinogenesis.

Molecular Weight: 58 kDa

Gene ID: 55693

NCBI Accession: NP_060509

Pathways: Warburg Effect