Growth Hormone Receptor antibody (AA 21-70)

Catalog No. ABIN6579402

The Rabbit Polyclonal anti-Growth Hormone Receptor antibody (ABIN6579402) specifically detects Growth Hormone Receptor in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Growth Hormone Receptor antibody (AA 21-70) (ABIN6579402)

Target: Growth Hormone Receptor (GHR)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Growth Hormone Receptor antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Growth Hormone Receptor Antibody

Binding Specificity: AA 21-70

Purpose: GHR Antibody

Specificity: GHR Polyclonal Antibody detects endogenous levels of GHR protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized peptide derived from the N-terminal region of human GHR. AA range:21-70

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for Growth Hormone Receptor

Target: Growth Hormone Receptor (GHR)

Alternative Name: GHR

Background:

Synonyms: GHR, Growth hormone receptor, GH receptor, Somatotropin receptor

Background: This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011],

Gene Name: GHR

Protein Name: Growth hormone receptor

Molecular Weight: '70 kDa

Gene ID: 2690

OMIM: 135620

UniProt: P10912

Pathways: NF-kappaB Signaling, JAK-STAT Signaling, Response to Growth Hormone Stimulus