GP5 antibody (AA 331-380)

Catalog No. ABIN6579452

The Rabbit Polyclonal anti-GP5 antibody (ABIN6579452) specifically detects GP5 in WB, FACS, IHC, ELISA and IF. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for GP5 antibody (AA 331-380) (ABIN6579452)

Target: GP5 (Glycoprotein V (Platelet) (GP5))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GP5 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Product Details anti-GP5 Antibody

Binding Specificity: AA 331-380

Purpose: CD42d/GPV Antibody

Specificity: CD42d Polyclonal Antibody detects endogenous levels of CD42d protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human GP5. AA range:331-380

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:10000.. IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for GP5

Target: GP5 (Glycoprotein V (Platelet) (GP5))

Alternative Name: GP5

Background:

Synonyms: GP5, Platelet glycoprotein V, GPV, Glycoprotein 5, CD42d

Background: Human platelet glycoprotein V (GP5) is a part of the Ib-V-IX system of surface glycoproteins that constitute the receptor for von Willebrand factor (VWF, MIM 613160) and mediate the adhesion of platelets to injured vascular surfaces in the arterial circulation, a critical initiating event in hemostasis. The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA, MIM 606672) and a beta chain (GP1BB, MIM 138720), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX (GP9, MIM 173515) and GP5. Mutations in GP1BA, GP1BB, and GP9 have been shown to cause Bernard-Soulier syndrome (MIM 231200), a bleeding disorder (review by Lopez et al., 1998 [PubMed 9616133]).[supplied by OMIM, Nov 2010],

Gene Name: GP5

Protein Name: Platelet glycoprotein V

Molecular Weight: 60 kDa

Gene ID: 2814

OMIM: 165095

UniProt: P40197