MACC1 antibody (AA 411-460)

Catalog No. ABIN6579596

The Rabbit Polyclonal anti-MACC1 antibody is suitable to detect MACC1 in samples from Human and Mouse. It has been validated for WB and ELISA.

Quick Overview for MACC1 antibody (AA 411-460) (ABIN6579596)

Target: MACC1 (Metastasis Associated in Colon Cancer 1 (MACC1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MACC1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-MACC1 Antibody

Binding Specificity: AA 411-460

Purpose: MACC1 Antibody

Specificity: MACC1 Polyclonal Antibody detects endogenous levels of MACC1 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human MACC1. AA range:411-460

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for MACC1

Target: MACC1 (Metastasis Associated in Colon Cancer 1 (MACC1))

Alternative Name: MACC1

Background:

Synonyms: MACC1, Metastasis-associated in colon cancer protein 1, SH3 domain-containing protein 7a5

Background: MACC1 is a key regulator of the hepatocyte growth factor (HGF, MIM 142409)-HGF receptor (HGFR, or MET, MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009 [PubMed 19098908]).[supplied by OMIM, Mar 2009],

Gene Name: MACC1

Protein Name: Metastasis-associated in colon cancer protein 1

Molecular Weight: 96 kDa

Gene ID: 346389

OMIM: 612646

UniProt: Q6ZN28