IL2RG antibody

Catalog No. ABIN6579821

This anti-IL2RG antibody is a Rat Monoclonal antibody detecting IL2RG in FACS. Suitable for Human and Dog.

Quick Overview for IL2RG antibody (ABIN6579821)

Target: IL2RG (Interleukin 2 Receptor, gamma (IL2RG))

Reactivity: Human, Dog

Host: Rat

Clonality: Monoclonal

Conjugate: This IL2RG antibody is un-conjugated

Application: Flow Cytometry (FACS)

Clone: TUGh4

Product Details anti-IL2RG Antibody

Purpose: Anti-Hu CD132 Purified

Specificity: The rat monoclonal antibody TUGh4 recognizes an extracellular epitope of CD132 (the common gamma chain), a 65-70 kDa type I transmembrane glycoprotein broadly expressed by most leukocytes.

Cross-Reactivity (Details): Human, Canine (Dog)

Purification: Purified by protein-G affinity chromatography.

Purity: > 95 % (by SDS-PAGE)

Immunogen: Human CD132-transfected cell line

Isotype: IgG2b kappa

Application Details

Application Notes: Flow cytometry: Recommended dilution: 1-4 μg/mL.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 2-8°C. Do not freeze.

Target Details for IL2RG

Target: IL2RG (Interleukin 2 Receptor, gamma (IL2RG))

Alternative Name: CD132

Background: Interleukin 2 receptor subunit gamma,CD132 / common gamma chain is an essential component of receptors for IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21, and it is critical for development of the immune system. Its mutation causes X-linked severe combined immunodeficiency disease (XSCID). CD132 is expressed on lymphocytes, NK cells, monocytes, and granulocytes. Through its cytoplasmic part which containsfour tyrosines and an SH2 domain, CD132 transcuces signal to downstream JAK/STAT pathway.,common gamma chain, IL2RG, SCIDX, IMD4

Gene ID: 3561

UniProt: P31785

Pathways: JAK-STAT Signaling, Growth Factor Binding